Review Glioblastoma multiforme – an overview

Glioblastoma multiforme – an overview

Glioblastoma multiforme is a central nervous system tumor of grade IV histological malignancy according to the WHO classification. Over 90% of diagnosed glioblastomas multiforme cases are primary gliomas, arising from normal glial cells through multistep oncogenesis. The remaining 10% are secondary gliomas originating from tumors of lower grade. These tumors expand distinctly more slowly. Altho...

Glioblastoma Multiforme : A Brief Review

mirnas in glioblastoma multiforme: a brief review

mirnas are endogenous small noncoding rnas that can regulate many cellular processes. different expression levels of several mirnas have been detected in glioblastomas. function of mirnas and targets have been well studied in recent years. according to these studies, the role of mirnas in glioblastoma pathogenesis have been defined. mirnas have affected many processes in gbm such as apoptosis, ...

Glioblastoma Multiforme: A Single Hospital Experience

Background & Aim: Glioblastoma multiforme (GBM), the highest grade glioma (grade IV), is the most malignant form of astrocytoma in adults. This study aimed at evaluating the relationship between demographic, clinical and medical factors with GBM outcome. Methods & Materials/Patients: Through a cross-sectional design, 58 patients with newly diagnosed GBM were studied from 1999 to 2015 in Guil...

Radiothermotherapy for glioblastoma multiforme: A preliminary study

Introduction: Glioblastoma multiforme (GBM) is a highly radioresistant cancer with low survival rate. Current therapy approaches have failed to treat GBM. The aim of this study was to assess how GBM tumors respond to combination of hyperthermia and radiotherapy. Materials and Methods:   In this study, 38 GBM patients were included. 19 patients were treated ...